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Issue 60, 2018
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Copper-catalyzed decarboxylative propargylation/hydroamination reactions: access to C3 β-ketoester-functionalized indoles

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Abstract

A copper-catalyzed reaction of ethynyl benzoxazinanones with readily accessible β-ketoesters via a decarboxylative propargylation/hydroamination sequence has been developed. This protocol furnished a diverse range of C3 β-ketoester-functionalized indoles in good to excellent yields.

Graphical abstract: Copper-catalyzed decarboxylative propargylation/hydroamination reactions: access to C3 β-ketoester-functionalized indoles

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Publication details

The article was received on 06 Jun 2018, accepted on 04 Jul 2018 and first published on 04 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04499F
Citation: Chem. Commun., 2018,54, 8375-8378
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    Copper-catalyzed decarboxylative propargylation/hydroamination reactions: access to C3 β-ketoester-functionalized indoles

    S. Wang, M. Liu, X. Chen, H. Wang and H. Zhai, Chem. Commun., 2018, 54, 8375
    DOI: 10.1039/C8CC04499F

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