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Issue 65, 2018

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

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Abstract

Substrate binding assays, in vitro proteolytic processing assays, and heterologous lasso peptide production were used to investigate the roles of conserved precursor peptide residues during paeninodin maturation. Specifically, we delineate which residues are important for substrate recognition, proteolysis, and lasso peptide macrocyclization.

Graphical abstract: Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

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Article information


Submitted
01 Jun 2018
Accepted
20 Jul 2018
First published
20 Jul 2018

Chem. Commun., 2018,54, 9007-9010
Article type
Communication

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

J. D. Hegemann, C. J. Schwalen, D. A. Mitchell and W. A. van der Donk, Chem. Commun., 2018, 54, 9007 DOI: 10.1039/C8CC04411B

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