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Iodine catalyzed reduction of quinolines under mild reaction conditions

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Abstract

A reduction of quinolines to synthetically versatile tetrahydroquinoline molecules with I2 and HBpin is described. In the presence of iodine (20 mol%) as a catalyst, reduction of quinolines and other N-heteroarenes proceeded readily with hydroboranes as the reducing reagents. The broad functional-group tolerance, good yields and mild reaction conditions imply high practical utility.

Graphical abstract: Iodine catalyzed reduction of quinolines under mild reaction conditions

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Publication details

The article was received on 29 May 2018, accepted on 09 Jul 2018 and first published on 11 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04262D
Citation: Chem. Commun., 2018, Advance Article
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    Iodine catalyzed reduction of quinolines under mild reaction conditions

    C. Yang, X. Chen, H. Li, W. Wei, Z. Yang and J. Chang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC04262D

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