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Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides

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Abstract

This study assessed the effects of artificial cationic oligopeptides on a DNA/RNA hybrid duplex. An oligopeptide containing the octamer of L-2,4-diaminobutyric acid (Dab8) was found to enhance both the RNase A resistance and RNase H activity of the DNA/RNA hybrid, which are important for developing nucleic acid drugs.

Graphical abstract: Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides

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Publication details

The article was received on 22 May 2018, accepted on 05 Jul 2018 and first published on 06 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04082F
Citation: Chem. Commun., 2018, Advance Article
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    Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides

    R. I. Hara, Y. Maeda, H. Fujimaki and T. Wada, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC04082F

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