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Issue 54, 2018
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Di-copper(II) DNA G-quadruplexes as EPR distance rulers

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Abstract

Artificial metal-base tetrads composed of square-planar CuII(pyridine)4 complexes were covalently attached to both the 3′ and 5′ ends of tetramolecular DNA G-quadruplexes [Ld(G3–5)LdT]4 (L = pyridine ligand) of different lengths. Owing to the planar four-point attachment of the metal complexes, the magnetic orbitals (dx2y2) of the d9-configured CuII cations are placed in a coplanar fashion, separated by the stacked guanine tetrads. Pulsed EPR-derived CuII–CuII distances and angles were found to be in agreement with those obtained from molecular dynamics simulations. DNA-confined transition metal spin labels open new ways to study oligonucleotide structure and DNA–protein complexes.

Graphical abstract: Di-copper(ii) DNA G-quadruplexes as EPR distance rulers

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Publication details

The article was received on 21 May 2018, accepted on 11 Jun 2018 and first published on 11 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC04053B
Citation: Chem. Commun., 2018,54, 7455-7458

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    Di-copper(II) DNA G-quadruplexes as EPR distance rulers

    D. M. Engelhard, A. Meyer, A. Berndhäuser, O. Schiemann and G. H. Clever, Chem. Commun., 2018, 54, 7455
    DOI: 10.1039/C8CC04053B

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