Jump to main content
Jump to site search

Issue 54, 2018
Previous Article Next Article

Di-copper(ii) DNA G-quadruplexes as EPR distance rulers

Author affiliations


Artificial metal-base tetrads composed of square-planar CuII(pyridine)4 complexes were covalently attached to both the 3′ and 5′ ends of tetramolecular DNA G-quadruplexes [Ld(G3–5)LdT]4 (L = pyridine ligand) of different lengths. Owing to the planar four-point attachment of the metal complexes, the magnetic orbitals (dx2y2) of the d9-configured CuII cations are placed in a coplanar fashion, separated by the stacked guanine tetrads. Pulsed EPR-derived CuII–CuII distances and angles were found to be in agreement with those obtained from molecular dynamics simulations. DNA-confined transition metal spin labels open new ways to study oligonucleotide structure and DNA–protein complexes.

Graphical abstract: Di-copper(ii) DNA G-quadruplexes as EPR distance rulers

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 May 2018, accepted on 11 Jun 2018 and first published on 11 Jun 2018

Article type: Communication
DOI: 10.1039/C8CC04053B
Chem. Commun., 2018,54, 7455-7458

  •   Request permissions

    Di-copper(II) DNA G-quadruplexes as EPR distance rulers

    D. M. Engelhard, A. Meyer, A. Berndhäuser, O. Schiemann and G. H. Clever, Chem. Commun., 2018, 54, 7455
    DOI: 10.1039/C8CC04053B

Search articles by author