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An anion receptor that facilitates transmembrane proton-anion symport by deprotonating its sulfonamide N−H proton

Abstract

Indole-based amide-sulfonamide derivatives were synthesized. The X-ray crystal structure and chloride binding studies in solution showed the 1:1 stoichiometry. The ion transport efficiency directly correlated to the pKa of the sulfonamide N−H protons. The mechanistic study indicated the proton-anion symport across the lipid bilayer membrane.

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Publication details

The article was received on 21 May 2018, accepted on 09 Aug 2018 and first published on 09 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC04044C
Citation: Chem. Commun., 2018, Accepted Manuscript
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    An anion receptor that facilitates transmembrane proton-anion symport by deprotonating its sulfonamide N−H proton

    S. V. Shinde and P. Talukdar, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC04044C

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