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Issue 73, 2018
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An anion receptor that facilitates transmembrane proton–anion symport by deprotonating its sulfonamide N–H proton

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Abstract

Indole-based amide-sulfonamide derivatives were synthesized. The X-ray crystal structure and chloride binding studies in solution showed a 1 : 1 stoichiometry. The ion transport efficiency directly correlated to the pKa of the sulfonamide N–H protons. The mechanistic study indicated proton–anion symport across the lipid bilayer membrane.

Graphical abstract: An anion receptor that facilitates transmembrane proton–anion symport by deprotonating its sulfonamide N–H proton

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Publication details

The article was received on 21 May 2018, accepted on 09 Aug 2018 and first published on 09 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC04044C
Citation: Chem. Commun., 2018,54, 10351-10354
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    An anion receptor that facilitates transmembrane proton–anion symport by deprotonating its sulfonamide N–H proton

    S. V. Shinde and P. Talukdar, Chem. Commun., 2018, 54, 10351
    DOI: 10.1039/C8CC04044C

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