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ALKBH5-induced demethylation of mono- and dimethylated adenosine

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Abstract

RNA contains methylated A-base derivatives. A methylation to m6A and then demethylation regulate homeostasis in mRNA. It is assumed that m6A is mainly demethylated by the α-ketoglutarate dependent oxidase ALKBH5. Here we show that ALKBH5 also demethylates the dimethylated adenosine m62A, which is a non-canonical base present in ribosomal RNA.

Graphical abstract: ALKBH5-induced demethylation of mono- and dimethylated adenosine

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Publication details

The article was received on 18 May 2018, accepted on 04 Jul 2018 and first published on 05 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC03980A
Citation: Chem. Commun., 2018, Advance Article
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    ALKBH5-induced demethylation of mono- and dimethylated adenosine

    T. T. Ensfelder, M. Q. Kurz, K. Iwan, S. Geiger, S. Matheisl, M. Müller, R. Beckmann and T. Carell, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC03980A

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