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Issue 62, 2018
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Palladium-catalyzed C(carbonyl)–C bond cleavage of amides: a facile access to phenylcarbamate derivatives with alcohols

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Abstract

A sulfur-containing auxiliary enabled palladium-catalyzed C(carbonyl)–C bond activation of amides was reported to form phenylcarbamate derivatives with alcohols. Both alkyl and benzyl alcohols could be employed well with yields up to 85%. Derivations from phenylcarbamates to ureas and thiocarbamates illustrated the potential applications of this sequential C–C cleavage/C–O coupling reaction.

Graphical abstract: Palladium-catalyzed C(carbonyl)–C bond cleavage of amides: a facile access to phenylcarbamate derivatives with alcohols

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Publication details

The article was received on 19 May 2018, accepted on 06 Jul 2018 and first published on 10 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC03954B
Citation: Chem. Commun., 2018,54, 8606-8609
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    Palladium-catalyzed C(carbonyl)–C bond cleavage of amides: a facile access to phenylcarbamate derivatives with alcohols

    X. Yan, H. Sun, H. Xiang, D. Yu, D. Luo and X. Zhou, Chem. Commun., 2018, 54, 8606
    DOI: 10.1039/C8CC03954B

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