Issue 69, 2018

Multicarbazole scaffolds for selective G-quadruplex binding

Abstract

Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.

Graphical abstract: Multicarbazole scaffolds for selective G-quadruplex binding

Supplementary files

Article information

Article type
Communication
Submitted
17 May 2018
Accepted
01 Aug 2018
First published
02 Aug 2018

Chem. Commun., 2018,54, 9647-9650

Multicarbazole scaffolds for selective G-quadruplex binding

A. Ou, A. Guédin, B. W. Skelton, S. Amrane, C. W. Evans, M. Norret, K. S. Iyer, J. Mergny and N. M. Smith, Chem. Commun., 2018, 54, 9647 DOI: 10.1039/C8CC03945C

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