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Multicarbazole scaffolds for selective G-quadruplex binding

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Abstract

Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.

Graphical abstract: Multicarbazole scaffolds for selective G-quadruplex binding

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Publication details

The article was received on 17 May 2018, accepted on 01 Aug 2018 and first published on 02 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC03945C
Citation: Chem. Commun., 2018, Advance Article
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    Multicarbazole scaffolds for selective G-quadruplex binding

    A. Ou, A. Guédin, B. W. Skelton, S. Amrane, C. W. Evans, M. Norret, K. S. Iyer, J. Mergny and N. M. Smith, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC03945C

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