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Issue 69, 2018
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Multicarbazole scaffolds for selective G-quadruplex binding

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Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.

Graphical abstract: Multicarbazole scaffolds for selective G-quadruplex binding

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The article was received on 17 May 2018, accepted on 01 Aug 2018 and first published on 02 Aug 2018

Article type: Communication
DOI: 10.1039/C8CC03945C
Citation: Chem. Commun., 2018,54, 9647-9650

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    Multicarbazole scaffolds for selective G-quadruplex binding

    A. Ou, A. Guédin, B. W. Skelton, S. Amrane, C. W. Evans, M. Norret, K. S. Iyer, J. Mergny and N. M. Smith, Chem. Commun., 2018, 54, 9647
    DOI: 10.1039/C8CC03945C

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