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A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy

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Abstract

We report a novel and easy-to-fabricate polynuclear nanoparticle based on the collaborative re-assembly of nanoparticles as a robust chemogene co-delivery platform. Specifically, the polynuclear nanoparticle carrying DOX and siBcl-2 exerts remarkable co-delivery efficiency, increases tumour cell apoptosis and inhibits tumour cell proliferation in vitro and in vivo.

Graphical abstract: A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy

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Publication details

The article was received on 08 May 2018, accepted on 13 Jul 2018 and first published on 13 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC03720E
Citation: Chem. Commun., 2018, Advance Article
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    A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy

    L. Xing, J. Zhang, T. Zhou, Y. He, P. Cui, J. Gong, M. Sun, J. Lu, Z. Huang, L. Jin and H. Jiang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC03720E

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