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Glucose Oxidase Mediated Targeted Cancer-Starving Therapy by Biotinylated Self-Assembled Vesicle

Abstract

Herein, we demonstrate Glucose oxidase (GOx) mediated targeted cancer-starving therapy by self-assembled vesicle of trimesic acid based biotinylated amphiphile (TMB). TMB vesicle entrapped GOx selectively killed cancer cells (HeLa, B16F10) with ~6-fold higher efficiency compared to non-cancer (CHO, NIH3T3) cells by blocking energy supply to tumor through oxidation of intracellular glucose.

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Publication details

The article was received on 04 May 2018, accepted on 02 Aug 2018 and first published on 03 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC03599G
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Glucose Oxidase Mediated Targeted Cancer-Starving Therapy by Biotinylated Self-Assembled Vesicle

    S. Dinda, S. Sarkar and P. K. Das, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC03599G

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