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Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles

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Abstract

Herein, we demonstrate glucose oxidase (GOx) mediated targeted cancer-starving therapy by self-assembled vesicle of trimesic acid based biotinylated amphiphile (TMB). The TMB vesicles entrapped GOx and selectively killed cancer cells (HeLa, B16F10), with ∼6-fold higher efficiency compared to non-cancer cells (CHO, NIH3T3), by blocking the energy supply to tumors through the oxidation of intracellular glucose.

Graphical abstract: Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles

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Publication details

The article was received on 04 May 2018, accepted on 02 Aug 2018 and first published on 03 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC03599G
Citation: Chem. Commun., 2018, Advance Article
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    Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles

    S. Dinda, S. Sarkar and P. K. Das, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC03599G

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