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Issue 62, 2018
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Structural differences between toxic and nontoxic HypF-N oligomers

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Abstract

We have studied two misfolded oligomeric forms of the protein HypF-N, which show similar morphologies but very different toxicities. We measured over 80 intermolecular distance-dependent parameters for each oligomer type using FRET, in conjunction with solution- and solid-state NMR and other biophysical techniques. The results indicate that the formation of a highly organised hydrogen bonded core in the toxic oligomers results in the exposure of a larger number of hydrophobic residues than in the nontoxic species, causing the former to form aberrant interactions with cellular components.

Graphical abstract: Structural differences between toxic and nontoxic HypF-N oligomers

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Publication details

The article was received on 27 Apr 2018, accepted on 10 Jul 2018 and first published on 11 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC03446J
Citation: Chem. Commun., 2018,54, 8637-8640
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    Structural differences between toxic and nontoxic HypF-N oligomers

    C. Capitini, J. R. Patel, A. Natalello, C. D’Andrea, A. Relini, J. A. Jarvis, L. Birolo, A. Peduzzo, M. Vendruscolo, P. Matteini, C. M. Dobson, A. De Simone and F. Chiti, Chem. Commun., 2018, 54, 8637
    DOI: 10.1039/C8CC03446J

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