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Issue 48, 2018
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Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies

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Abstract

The first systematic investigation of the effect of high mannose, hybrid, and bi- and tri-antennary complex type glycans on the effector functions of antibodies was achieved by the discovery of novel Endo-S2 mutants generated by site-directed mutagenesis as glycosynthases with broad substrate specificity.

Graphical abstract: Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies

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Article information


Submitted
30 Apr 2018
Accepted
21 May 2018
First published
29 May 2018

Chem. Commun., 2018,54, 6161-6164
Article type
Communication

Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies

S. S. Shivatare, L. Huang, Y. Zeng, J. Liao, T. You, S. Wang, T. Cheng, C. Chiu, P. Chao, L. Chen, T. Tsai, C. Huang, C. Wu, N. Lin and C. Wong, Chem. Commun., 2018, 54, 6161
DOI: 10.1039/C8CC03384F

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