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Issue 50, 2018
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Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

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Abstract

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol–ene and strain promoted azide–alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively.

Graphical abstract: Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

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Article information


Submitted
27 Apr 2018
Accepted
24 May 2018
First published
29 May 2018

Chem. Commun., 2018,54, 6923-6926
Article type
Communication

Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

P. J. LeValley, E. M. Ovadia, C. A. Bresette, L. A. Sawicki, E. Maverakis, S. Bai and A. M. Kloxin, Chem. Commun., 2018, 54, 6923
DOI: 10.1039/C8CC03218A

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