Issue 49, 2018
From the journal:

Chemical Communications

A mitochondria-targeting hetero-binuclear Ir(iii)–Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells†

Cheng Ouyang, ORCID logo a   Lei Chen,b   Thomas W. Rees,a   Yu Chen,*a   Jiankang Liu,b   Liangnian Ji,a   Jiangang Long*b  and  Hui Chao ORCID logo *a  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, P. R. China
E-mail: ceschh@mail.sysu.edu.cn, chenyu63@mail.sysu.edu.cn

b Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P. R. China
E-mail: jglong@mail.xjtu.edu.cn

Abstract

A hetero-binuclear Ir(III)–Pt(II) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.

Graphical abstract: A mitochondria-targeting hetero-binuclear Ir(iii)–Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells

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Article information

DOI
https://doi.org/10.1039/C8CC02795A
Article type
Communication
Submitted
08 Apr 2018
Accepted
25 May 2018
First published
25 May 2018

Chem. Commun., 2018,54, 6268-6271

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A mitochondria-targeting hetero-binuclear Ir(III)–Pt(II) complex induces necrosis in cisplatin-resistant tumor cells

C. Ouyang, L. Chen, T. W. Rees, Y. Chen, J. Liu, L. Ji, J. Long and H. Chao, Chem. Commun., 2018, 54, 6268 DOI: 10.1039/C8CC02795A

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