Issue 40, 2018
From the journal:

Chemical Communications

An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria†

Ivan Di Bonaventura,a   Stéphane Baeriswyl,a   Alice Capecchi,a   Bee-Ha Gan,a   Xian Jin,a   Thissa N. Siriwardena,a   Runze He,b   Thilo Köhler,c   Arianna Pompilio,d   Giovanni Di Bonaventura,d   Christian van Delden,c   Sacha Javora  and  Jean-Louis Reymond ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
E-mail: jean-louis.reymond@dcb.unibe.ch

b Shanghai Space Peptides Pharmaceutical Co. Ltd, Shanghai, China

c Department of Microbiology and Molecular Medicine, University of Geneva, and Service of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland

d Department of Biomedical, Oral and Biotechnological Sciences and Center of Excellence on Aging and Translational Medicine (CeSI-MeT), G. d’Annunzio, University of Chieti-Pescara, Via dei Vestini 31, Chieti, Italy

Abstract

We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa.

Graphical abstract: An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria

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Article information

DOI
https://doi.org/10.1039/C8CC02412J
Article type
Communication
Submitted
26 Mar 2018
Accepted
23 Apr 2018
First published
23 Apr 2018

Chem. Commun., 2018,54, 5130-5133

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An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria

I. Di Bonaventura, S. Baeriswyl, A. Capecchi, B. Gan, X. Jin, T. N. Siriwardena, R. He, T. Köhler, A. Pompilio, G. Di Bonaventura, C. van Delden, S. Javor and J. Reymond, Chem. Commun., 2018, 54, 5130 DOI: 10.1039/C8CC02412J

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