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Issue 56, 2018
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Fluorescence quenching by lipid encased nanoparticles shows that amyloid-β has a preferred orientation in the membrane

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Abstract

Short range plasmonic fields around a nanoparticle can modulate fluorescence or Raman processes. In lipid encased nanoparticles, this can potentially measure the relative depths of different parts of a membrane protein from the surface. We employ this technique to discover that membrane inserted amyloid-β oligomers have a preferred molecular orientation.

Graphical abstract: Fluorescence quenching by lipid encased nanoparticles shows that amyloid-β has a preferred orientation in the membrane

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Article information


Submitted
16 Mar 2018
Accepted
24 May 2018
First published
24 May 2018

Chem. Commun., 2018,54, 7750-7753
Article type
Communication

Fluorescence quenching by lipid encased nanoparticles shows that amyloid-β has a preferred orientation in the membrane

B. Chandra, B. K. Maity, A. Das and S. Maiti, Chem. Commun., 2018, 54, 7750
DOI: 10.1039/C8CC02108B

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