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Issue 42, 2018
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Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays

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Abstract

The inhibitor for the homophilic dimerization of P-cadherin was discovered by SPR-based screening using fragment compounds. Our SPR assays identified a specific P-cadherin binder, which was able to inhibit the cell adhesion of living CHO cells that expressed P-cadherin.

Graphical abstract: Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays

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Publication details

The article was received on 12 Mar 2018, accepted on 28 Apr 2018 and first published on 09 May 2018


Article type: Communication
DOI: 10.1039/C8CC01964A
Chem. Commun., 2018,54, 5350-5353

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    Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays

    A. Senoo, S. Nagatoishi, A. Moberg, L. N. Babol, T. Mitani, T. Tashima, S. Kudo and K. Tsumoto, Chem. Commun., 2018, 54, 5350
    DOI: 10.1039/C8CC01964A

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