Issue 33, 2018
From the journal:

Chemical Communications

Oxidation-induced generation of a mild electrophile for proximity-enhanced protein–protein crosslinking†‡

X. Shang,a   Y. Chen,a   N. Wang,a   W. Niu ORCID logo b  and  J. Guo ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA
E-mail: jguo4@unl.edu

b Department of Chemical & Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

Abstract

We report a strategy to introduce a reactive electrophile into proteins through the conversion of a chemically inert group into a bioreactive group in response to an inducer molecule. This strategy was demonstrated by oxidation-induced and proximity-enhanced protein–protein crosslinking in the presence of a large excess of free nucleophile.

Graphical abstract: Oxidation-induced generation of a mild electrophile for proximity-enhanced protein–protein crosslinking

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Article information

DOI
https://doi.org/10.1039/C8CC01639A
Article type
Communication
Submitted
27 Feb 2018
Accepted
24 Mar 2018
First published
26 Mar 2018

Chem. Commun., 2018,54, 4172-4175

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Oxidation-induced generation of a mild electrophile for proximity-enhanced protein–protein crosslinking

X. Shang, Y. Chen, N. Wang, W. Niu and J. Guo, Chem. Commun., 2018, 54, 4172 DOI: 10.1039/C8CC01639A

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