Issue 29, 2018

A divergent and concise total synthesis of (−)-lycoposerramine R and (+)-lycopladine A

Abstract

A concise, asymmetric and divergent synthesis of lycoposerramine R and lycopladine A is presented. The synthesis features the palladium-catalyzed cycloalkenylation of a silyl enol ether for assembling the 5/6-hydrindane system and generating a quaternary carbon center in one step.

Graphical abstract: A divergent and concise total synthesis of (−)-lycoposerramine R and (+)-lycopladine A

Supplementary files

Article information

Article type
Communication
Submitted
27 Feb 2018
Accepted
08 Mar 2018
First published
09 Mar 2018

Chem. Commun., 2018,54, 3598-3600

A divergent and concise total synthesis of (−)-lycoposerramine R and (+)-lycopladine A

S. Chen, J. Wang and F. G. Qiu, Chem. Commun., 2018, 54, 3598 DOI: 10.1039/C8CC01626G

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