Issue 63, 2018
From the journal:

Chemical Communications

A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice†

Akihiro Ogura, ORCID logo a   Sayaka Urano,a   Tsuyoshi Tahara,b   Satoshi Nozaki,b   Regina Sibgatullina,ac   Kenward Vong,a   Takehiro Suzuki,d   Naoshi Dohmae,d   Almira Kurbangalieva, ORCID logo c   Yasuyoshi Watanabeb  and  Katsunori Tanaka ORCID logo *ace  

* Corresponding authors

a Biofunctional Synthetic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako-shi, Saitama, Japan
E-mail: kotzenori@riken.jp

b Center for Life Science Technologies, RIKEN, Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, Japan

c Biofunctional Chemistry Laboratory, A. Butlerov Institute of Chemistry, Kazan Federal University, 18 Kremlyovskaya street, Kazan, Russia

d Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako-shi, Saitama, Japan

e GlycoTargeting Research Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, Japan

Abstract

This work represents the first broad study of testing diverse heterogenous glycoconjugates (7 different glycoalbumins) for their differential in vivo binding (11 different cancer cell types) in both cell- and animal-based studies. As a result, various changes in biodistribution, excretion, and even tumor adhesion were observed.

Graphical abstract: A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice

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Article information

DOI
https://doi.org/10.1039/C8CC01544A
Article type
Communication
Submitted
24 Feb 2018
Accepted
25 Jun 2018
First published
25 Jun 2018

Chem. Commun., 2018,54, 8693-8696

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A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice

A. Ogura, S. Urano, T. Tahara, S. Nozaki, R. Sibgatullina, K. Vong, T. Suzuki, N. Dohmae, A. Kurbangalieva, Y. Watanabe and K. Tanaka, Chem. Commun., 2018, 54, 8693 DOI: 10.1039/C8CC01544A

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