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Issue 43, 2018
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Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

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Abstract

Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.

Graphical abstract: Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

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Article information


Submitted
07 Feb 2018
Accepted
23 Apr 2018
First published
27 Apr 2018

Chem. Commun., 2018,54, 5422-5425
Article type
Communication

Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

C. Cantarutti, G. Raj, F. Fogolari, S. Giorgetti, A. Corazza, V. Bellotti, P. Naumov and G. Esposito, Chem. Commun., 2018, 54, 5422
DOI: 10.1039/C8CC01053F

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