Palladium-catalyzed site-selective arylation of aliphatic ketones enabled by a transient ligand†
Abstract
Transition metal-catalyzed direct C–H bond functionalization enabled by transient ligands has become an attractive topic. Here we report a palladium-catalyzed site-selective arylation of β-C(sp3)–H bonds in aliphatic ketones with β-alanine as the transient ligand.