Issue 25, 2018
From the journal:

Chemical Communications

Copper-catalyzed decarboxylative cyclization via tandem C–P and C–N bond formation: access to 2-phosphorylmethyl indoles†

Bao-Cheng Wang,‡a   Ya-Ni Wang,‡a   Mao-Mao Zhang,a   Wen-Jing Xiao ORCID logo ab  and  Liang-Qiu Lu ORCID logo *ac  

* Corresponding authors

a CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China
E-mail: luliangqiu@mail.ccnu.edu.cn

b Hubei Key Laboratory for Processing and Application of Catalytic Materials, Huanggang Normal College, Huanggang 438000, China

c State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, China

Abstract

A novel copper-catalyzed decarboxylative cyclization of ethynyl benzoxazinanones with P(O)H compounds has been developed. This protocol leads to a series of 2-phosphorylmethyl indoles with high efficiency and selectivity (up to 99% yield) through tandem C–P/C–N bond formation under mild conditions.

Graphical abstract: Copper-catalyzed decarboxylative cyclization via tandem C–P and C–N bond formation: access to 2-phosphorylmethyl indoles

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Article information

DOI
https://doi.org/10.1039/C8CC00739J
Article type
Communication
Submitted
29 Jan 2018
Accepted
04 Mar 2018
First published
07 Mar 2018

Chem. Commun., 2018,54, 3154-3157

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Copper-catalyzed decarboxylative cyclization via tandem C–P and C–N bond formation: access to 2-phosphorylmethyl indoles

B. Wang, Y. Wang, M. Zhang, W. Xiao and L. Lu, Chem. Commun., 2018, 54, 3154 DOI: 10.1039/C8CC00739J

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