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Issue 26, 2018
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A 18F radiolabelled Zn(ii) sensing fluorescent probe

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A selective fluorescent probe for Zn(II), AQA-F, has been synthesized. AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(II) ([AQA-F] = 0.1 mM, [Zn(II)Cl2] = 0–300 μM). An enhancement of quantum yield from Φ = 4.2% to Φ = 35% is also observed. AQA-F has a binding constant, Kd = 15.2 μM with Zn(II). This probe has been shown to respond to endogenous Zn(II) levels in vitro in prostate and prostate cancer cell lines. [18F]AQA-F has been synthesized with a radiochemical yield of 8.6% and a radiochemical purity of 97% in 88 minutes. AQA-F shows the potential for a dual modal PET/fluorescence imaging probe for Zn(II).

Graphical abstract: A 18F radiolabelled Zn(ii) sensing fluorescent probe

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Article information

26 Jan 2018
05 Mar 2018
First published
05 Mar 2018

Chem. Commun., 2018,54, 3227-3230
Article type

A 18F radiolabelled Zn(II) sensing fluorescent probe

T. W. Price, G. Firth, C. J. Eling, M. Kinnon, N. J. Long, J. Sturge and G. J. Stasiuk, Chem. Commun., 2018, 54, 3227
DOI: 10.1039/C8CC00687C

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