A chiral aluminum solvating agent (CASA) for 1H NMR chiral analysis of alcohols at low temperature†
A chiral aluminum solvating agent (CASA) was demonstrated to be a general and efficient reagent for 1H NMR chiral analysis of alcohols. The sodium salt of the CASA (CASA-Na) showed a complete baseline peak separation of the hydroxyl group for various chiral alcohols including primary, secondary, and tertiary alcohols with alkyl and aryl substituents in CD3CN. Due to the weak intermolecular interaction, 1H NMR measurement at low temperature (−40 to 10 °C) was required.
- This article is part of the themed collections: Celebrating the 75th Anniversary of the Korean Chemical Society (KCS) and 2018 Emerging Investigators