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Issue 24, 2018
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Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives

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Abstract

Novel stable tellurium-containing carbohydrate derivatives are prepared from hexitols and pentitols through a double nucleophilic substitution with NaHTe in PEG-400. These tellurosugars react at very high rates with two-electron oxidants, including hypochlorous and peroxynitrous acid, formed at sites of inflammation, and show considerable promise as protective agents against oxidative damage.

Graphical abstract: Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives

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Article information


Submitted
23 Jan 2018
Accepted
23 Feb 2018
First published
26 Feb 2018

Chem. Commun., 2018,54, 2990-2993
Article type
Communication

Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives

E. L. Borges, M. T. Ignasiak, Y. Velichenko, G. Perin, C. A. Hutton, M. J. Davies and C. H. Schiesser, Chem. Commun., 2018, 54, 2990
DOI: 10.1039/C8CC00565F

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