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Issue 16, 2018
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Versatile synthesis of functionalized β- and γ-carbolines via Pd-catalyzed C–H addition to nitriles/cyclization sequences

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Abstract

The first example of versatile synthesis of functionalized β-carbolines and γ-carbolines via redox-free Pd-catalyzed C–H addition of indole to nitrile/cyclization sequences is reported. A wide range of functionalized β-carbolines and γ-carbolines can be prepared from readily accessible indoles and nitriles in good to excellent yields under the optimal conditions.

Graphical abstract: Versatile synthesis of functionalized β- and γ-carbolines via Pd-catalyzed C–H addition to nitriles/cyclization sequences

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Supplementary files

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Submitted
03 Jan 2018
Accepted
01 Feb 2018
First published
01 Feb 2018

Chem. Commun., 2018,54, 2048-2051
Article type
Communication

Versatile synthesis of functionalized β- and γ-carbolines via Pd-catalyzed C–H addition to nitriles/cyclization sequences

T. Wang, D. Zhang and W. Liao, Chem. Commun., 2018, 54, 2048
DOI: 10.1039/C8CC00040A

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