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Issue 31, 2018
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Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis

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Abstract

The specificity of carbohydrate transporters towards their substrates poses a significant challenge for the development of molecular probes to monitor sugar uptake in cells for biochemical and biomedical applications. Herein we report a new set of coumarin-based fluorescent sugar conjugates applicable for the analysis of fructose uptake due to their free passage through the fructose-specific transporter GLUT5. The reported probes cover a broad range of the fluorescence spectrum providing essential tools for the evaluation of fructose transport capacity in live cells.

Graphical abstract: Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis

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Publication details

The article was received on 04 Jan 2018, accepted on 19 Mar 2018 and first published on 19 Mar 2018


Article type: Communication
DOI: 10.1039/C7CC09809J
Citation: Chem. Commun., 2018,54, 3855-3858

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    Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis

    V. V. Begoyan, Ł. J. Weseliński, S. Xia, J. Fedie, S. Kannan, A. Ferrier, S. Rao and M. Tanasova, Chem. Commun., 2018, 54, 3855
    DOI: 10.1039/C7CC09809J

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