Issue 11, 2018
From the journal:

Chemical Communications

A luminescent bimetallic iridium(iii) complex for ratiometric tracking intracellular viscosity†

Fengyu Liu,*ab   Jia Wen,c   Su-Shing Chen*b  and  Shiguo Sun ORCID logo *d  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, No. 2 linggong Road, Ganjingzi, District, China
E-mail: liufengyu@dlut.edu.cn

b Systems Biology Laboratory, Department of Computer Information Science and Engineering, University of Florida, Gainesville, FL, USA
E-mail: suchen@cise.ufl.edu

c Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China
E-mail: sunsg@nwsuaf.edu.cn

d Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, China
E-mail: sunsg@nwsuaf.edu.cn

Abstract

A luminescent bimetallic iridium probe C10 was developed through a long soft carbon chain linkage to achieve ratiometric detection of viscosity. C10 features high sensitivity and selectivity for viscosity. More importantly, C10 is living cell permeable and can be employed to distinguish cancer cells from normal cells and track viscosity changes during MCF-7 cell apoptosis.

Graphical abstract: A luminescent bimetallic iridium(iii) complex for ratiometric tracking intracellular viscosity

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Article information

DOI
https://doi.org/10.1039/C7CC09723A
Article type
Communication
Submitted
20 Dec 2017
Accepted
16 Jan 2018
First published
16 Jan 2018

Chem. Commun., 2018,54, 1371-1374

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A luminescent bimetallic iridium(III) complex for ratiometric tracking intracellular viscosity

F. Liu, J. Wen, S. Chen and S. Sun, Chem. Commun., 2018, 54, 1371 DOI: 10.1039/C7CC09723A

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