Jump to main content
Jump to site search

Issue 14, 2018
Previous Article Next Article

Enzymatically-stable oxetane-based dipeptide hydrogels

Author affiliations


Low molecular weight gelators that are not easily degraded by enzymes have a range of potential applications. Here, we report new Fmoc-protected dipeptides in which the amide carbonyl group has been replaced by an oxetane ring. Remarkably one of these peptidomimetics, but not the corresponding dipeptide, is an effective gelator, forming hydrogels at a concentration of 3 mg mL−1. On assembly, there is a lack of beta-sheet structure, implying that there is no requirement for this motif in such a gel. Furthermore, the modified dipeptide is also stable to proteolysis compared to the parent dipeptide.

Graphical abstract: Enzymatically-stable oxetane-based dipeptide hydrogels

Back to tab navigation

Supplementary files

Article information

19 Dec 2017
22 Jan 2018
First published
24 Jan 2018

This article is Open Access

Chem. Commun., 2018,54, 1793-1796
Article type

Enzymatically-stable oxetane-based dipeptide hydrogels

L. McDougall, E. R. Draper, J. D. Beadle, M. Shipman, P. Raubo, A. G. Jamieson and D. J. Adams, Chem. Commun., 2018, 54, 1793
DOI: 10.1039/C7CC09701H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Social activity

Search articles by author