Issue 19, 2018

Spatially resolved coding of λ-orthogonal hydrogels by laser lithography

Abstract

A λ-orthogonal reaction system is introduced, where visible light induced radical thiol–ene and UV light induced NITEC (Nitrile-Imine mediated Tetrazole–Ene Conjugation) ligations are consecutively employed to fabricate and functionalize PEG-based hydrogels. The fluorescent pyrazoline cycloadducts from the NITEC reaction are exploited to visualize the written structures within the hydrogels as well as to attach RGD containing functional groups to promote spatially resolved cell attachment on the hydrogel surface.

Graphical abstract: Spatially resolved coding of λ-orthogonal hydrogels by laser lithography

Supplementary files

Article information

Article type
Communication
Submitted
15 Dec 2017
Accepted
07 Feb 2018
First published
19 Feb 2018

Chem. Commun., 2018,54, 2436-2439

Spatially resolved coding of λ-orthogonal hydrogels by laser lithography

R. R. Batchelor, E. Blasco, K. N. R. Wuest, H. Lu, M. Wegener, C. Barner-Kowollik and M. H. Stenzel, Chem. Commun., 2018, 54, 2436 DOI: 10.1039/C7CC09619D

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