Facile meltPEGylation of flame-made luminescent Tb3+-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica

Kerda Keevend; Guido Panzarasa; Fabian H. L. Starsich; Martin Zeltner; Anastasia Spyrogianni; Elena Tsolaki; Giuseppino Fortunato; Sotiris E. Pratsinis; Sergio Bertazzo; Inge K. Herrmann

doi:10.1039/C7CC09402G

Facile meltPEGylation of flame-made luminescent Tb³⁺-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica†

Kerda Keevend,‡^a Guido Panzarasa,

‡^b Fabian H. L. Starsich,^c Martin Zeltner,^d Anastasia Spyrogianni,^cf Elena Tsolaki,^e Giuseppino Fortunato,^b Sotiris E. Pratsinis,

^c Sergio Bertazzo^e and Inge K. Herrmann

*^a

Author affiliations

* Corresponding authors

^a Particles Biology Interactions, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, St. Gallen, Switzerland
E-mail: inge.herrmann@empa.ch

^b Biomimetic Membranes and Textiles, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, St. Gallen, Switzerland

^c Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland

^d Functional Materials Laboratory, Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, CH-8093 Zurich, Switzerland

^e Departments of Medical Physics and Biomedical Engineering, University College London (UCL), Malet Place Engineering Building, London, UK

^f Currently at Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland

Abstract

Flame aerosol technology is a versatile method for scalable synthesis of nanoparticles. Since particles are produced and collected in a dry state, dispersibility and further functionalization could pose hurdles to their biomedical use. We report on a one-pot, scalable and robust procedure for the PEGylation of flame-made yttria and silica nanoparticles. We demonstrate improved colloidal stability, attenuated activation of blood coagulation and decreased uptake into phagocytic cells, all of which pave the way for facilitated biomedical use of flame-made oxide nanoparticles.

Chemical Communications

Facile meltPEGylation of flame-made luminescent Tb³⁺-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica†

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Facile meltPEGylation of flame-made luminescent Tb³⁺-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica

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