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Issue 21, 2018
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The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of 225Ac-labelled radioimmunoconjugates

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Abstract

The inverse electron-demand Diels–Alder reaction between tetrazine (Tz) and trans-cyclooctene (TCO) facilitates the efficient radiosynthesis of 225Ac-labelled radioimmunoconjugates in a two-step method, outperforming conventional approaches based on isothiocyanate couplings.

Graphical abstract: The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of 225Ac-labelled radioimmunoconjugates

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Article information


Submitted
27 Nov 2017
Accepted
26 Jan 2018
First published
26 Jan 2018

Chem. Commun., 2018,54, 2599-2602
Article type
Communication

The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of 225Ac-labelled radioimmunoconjugates

S. Poty, R. Membreno, J. M. Glaser, A. Ragupathi, W. W. Scholz, B. M. Zeglis and J. S. Lewis, Chem. Commun., 2018, 54, 2599
DOI: 10.1039/C7CC09129J

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