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Issue 12, 2018
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Naphthalimide derivatives as multifunctional molecules for detecting 5-formylpyrimidine by both PAGE analysis and dot-blot assays

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Abstract

An azide and hydrazine tethered to a naphthalimide analogue was created to selectively react with 5-formyluracil in one system and fluorogenically label 5-formylcytosine in another system. A biotin group was also introduced by copper-free click chemistry through selective labelling of the aldehyde present in 5-formylpyrimidine.

Graphical abstract: Naphthalimide derivatives as multifunctional molecules for detecting 5-formylpyrimidine by both PAGE analysis and dot-blot assays

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Publication details

The article was received on 12 Nov 2017, accepted on 16 Jan 2018 and first published on 16 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC08715B
Citation: Chem. Commun., 2018,54, 1497-1500

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    Naphthalimide derivatives as multifunctional molecules for detecting 5-formylpyrimidine by both PAGE analysis and dot-blot assays

    Y. Wang, C. Liu, W. Yang, G. Zou, X. Zhang, F. Wu, S. Yu, X. Luo and X. Zhou, Chem. Commun., 2018, 54, 1497
    DOI: 10.1039/C7CC08715B

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