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Issue 1, 2018
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Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

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Abstract

The expedient synthesis of compounds enriched in sp3 character is key goal in modern drug discovery. Herein, we report how a single pot Suzuki–Miyaura-hydrogenation can be used to furnish lead and fragment-like products in good to excellent yields. The approach has been successfully applied in formats amenable to parallel synthesis, in an asymmetric sense, and in the preparation of molecules with annotated biological activity.

Graphical abstract: Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

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Article information


Submitted
10 Nov 2017
Accepted
27 Nov 2017
First published
27 Nov 2017

Chem. Commun., 2018,54, 46-49
Article type
Communication

Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

P. S. Campbell, C. Jamieson, I. Simpson and A. J. B. Watson, Chem. Commun., 2018, 54, 46
DOI: 10.1039/C7CC08670A

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