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Issue 15, 2018
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Immobilization of membrane proteins on solid supports using functionalized β-sheet peptides and click chemistry

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Abstract

We have developed two functionalized β-sheet peptides (FBPs) and demonstrated that they can stabilize a variety of integral membrane proteins (IMPs), and most importantly allow covalent crosslinking of the IMPs onto solid supports via the highly selective click chemistry. The FBPs are promising tools for the preparation of IMP-based biomaterials or biosensors.

Graphical abstract: Immobilization of membrane proteins on solid supports using functionalized β-sheet peptides and click chemistry

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Article information


Submitted
10 Nov 2017
Accepted
25 Jan 2018
First published
25 Jan 2018

Chem. Commun., 2018,54, 1889-1892
Article type
Communication

Immobilization of membrane proteins on solid supports using functionalized β-sheet peptides and click chemistry

H. Hoi, A. Jiménez Castellanos, M. Aminpour, Y. He, H. Zhou, S. Abraham and C. D. Montemagno, Chem. Commun., 2018, 54, 1889
DOI: 10.1039/C7CC08652K

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