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Issue 15, 2018
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Immobilization of membrane proteins on solid supports using functionalized β-sheet peptides and click chemistry

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Abstract

We have developed two functionalized β-sheet peptides (FBPs) and demonstrated that they can stabilize a variety of integral membrane proteins (IMPs), and most importantly allow covalent crosslinking of the IMPs onto solid supports via the highly selective click chemistry. The FBPs are promising tools for the preparation of IMP-based biomaterials or biosensors.

Graphical abstract: Immobilization of membrane proteins on solid supports using functionalized β-sheet peptides and click chemistry

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Publication details

The article was received on 10 Nov 2017, accepted on 25 Jan 2018 and first published on 25 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC08652K
Chem. Commun., 2018,54, 1889-1892

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    Immobilization of membrane proteins on solid supports using functionalized β-sheet peptides and click chemistry

    H. Hoi, A. Jiménez Castellanos, M. Aminpour, Y. He, H. Zhou, S. Abraham and C. D. Montemagno, Chem. Commun., 2018, 54, 1889
    DOI: 10.1039/C7CC08652K

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