An absorbance enhanced probe based on gold nanoparticles (GNPs) was proposed for a protein assay in the cerebrospinal fluid of a rat brain. The GNPs, assembled with two aptamers by proximity ligation, have high anti-salt properties, and good selectivity and response toward proteins, such as interferon-gamma, in the brain.
J. Mao, M. Xu, W. Ji and M. Zhang, Chem. Commun., 2018, 54, 1193 DOI: 10.1039/C7CC08636A
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