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Issue 7, 2018
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Chemoselective triazole-phosphonamidate conjugates suitable for photorelease

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Abstract

Herein, we describe a new method for the conjugation of azide-containing target compounds that can be readily released as amines by irradiation with near UV light. This concept is based on a two-step protocol employing the chemoselective CuAAC and Staudinger-phosphonite reactions to deliver photo-cleavable phosphonamidate conjugates in high yields starting from 2-nitrobenzyl substituted phosphonites.

Graphical abstract: Chemoselective triazole-phosphonamidate conjugates suitable for photorelease

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Article information


Submitted
08 Nov 2017
Accepted
13 Dec 2017
First published
14 Dec 2017

Chem. Commun., 2018,54, 763-766
Article type
Communication

Chemoselective triazole-phosphonamidate conjugates suitable for photorelease

K. D. Siebertz and C. P. R. Hackenberger, Chem. Commun., 2018, 54, 763
DOI: 10.1039/C7CC08605A

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