Jump to main content
Jump to site search

Issue 5, 2018
Previous Article Next Article

Bioinspired design of a hybrid bifunctional enzymatic/organic electrocatalyst for site selective alcohol oxidation

Author affiliations

Abstract

This work combines the thermostable alcohol dehydrogenase D (AdhD) from Pyrococcus furiosus and the organic electrocatalyst TEMPO to create a bifunctional catalyst that selectively oxidizes primary and secondary alcohols. The active sites function independently, can be switched on by changing reaction conditions, and can selectively oxidize a mixture of 1- and 2-butanol. The NAD+-dependent enzyme catalyses the secondary alcohol oxidation at a rate 3-fold faster than the primary alcohol, while the covalently attached 4-glycidyl-TEMPO oxidizes 1-butanol and has negligible activity toward 2-butanol. This hybrid catalytic approach has potential value for selective alcohol oxidations as well as other electrochemical and enzymatic multistep processes in energy conversion and chemical synthesis.

Graphical abstract: Bioinspired design of a hybrid bifunctional enzymatic/organic electrocatalyst for site selective alcohol oxidation

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Nov 2017, accepted on 13 Dec 2017 and first published on 13 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC08548F
Chem. Commun., 2018,54, 491-494

  •   Request permissions

    Bioinspired design of a hybrid bifunctional enzymatic/organic electrocatalyst for site selective alcohol oxidation

    L. Lancaster, D. P. Hickey, M. S. Sigman, S. D. Minteer and I. Wheeldon, Chem. Commun., 2018, 54, 491
    DOI: 10.1039/C7CC08548F

Search articles by author

Spotlight

Advertisements