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Issue 5, 2018
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Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups

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Abstract

Methyltransferases are powerful tools for site-specific transfer of non-natural functional groups from synthetic analogs of their cosubstrate S-adenosyl-L-methionine (AdoMet). We present a new class of AdoMet analogs containing photo-caging (PC) groups in their side chain, enzymatic transfer of PC groups by a promiscuous DNA MTase as well as light-triggered removal from the target DNA. This strategy provides a new avenue to reversibly modulate the functionality of DNA at MTase target sites.

Graphical abstract: Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups

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Supplementary files

Article information


Submitted
27 Oct 2017
Accepted
23 Nov 2017
First published
24 Nov 2017

This article is Open Access

Chem. Commun., 2018,54, 449-451
Article type
Communication

Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups

L. Anhäuser, F. Muttach and A. Rentmeister, Chem. Commun., 2018, 54, 449
DOI: 10.1039/C7CC08300A

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