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Issue 4, 2018
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Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell

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Abstract

We report the synthesis of ABA′ triblock peptide–polysarcosine–peptide conjugates featuring two complementary phenylalanine–histidine pentapeptide strands A/A′. These sequences encode for antiparallel β-sheet formation into folded conjugates, which promote the self-assembly into polysarcosine-shielded core–shell nanorods. These do not cause aggregation of serum proteins in human blood plasma underlining an enhanced stability.

Graphical abstract: Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell

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Article information


Submitted
20 Oct 2017
Accepted
10 Dec 2017
First published
11 Dec 2017

Chem. Commun., 2018,54, 401-404
Article type
Communication

Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell

R. Otter, K. Klinker, D. Spitzer, M. Schinnerer, M. Barz and P. Besenius, Chem. Commun., 2018, 54, 401
DOI: 10.1039/C7CC08127H

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