Issue 5, 2018

Water soluble two-photon fluorescent organic probes for long-term imaging of lysosomes in live cells and tumor spheroids

Abstract

The morphological alteration of lysosomes is a powerful indicator of various pathological disorders. In this regard, we have designed and synthesized a new water soluble fluorescent Schiff-base ligand (L-lyso) containing two hydroxyl groups. L-lyso exhibits excellent two-photon properties with tracking of lysosomes in live cells as well as in 3D tumor spheroids. Furthermore, it can label lysosomes for more than 3 days. Thus, L-lyso has an edge over the commercially available expensive LysoTracker probes and also over other reported probes in terms of its long-term imaging, water solubility and facile synthesis.

Graphical abstract: Water soluble two-photon fluorescent organic probes for long-term imaging of lysosomes in live cells and tumor spheroids

Supplementary files

Article information

Article type
Communication
Submitted
09 Oct 2017
Accepted
13 Dec 2017
First published
13 Dec 2017

Chem. Commun., 2018,54, 539-542

Water soluble two-photon fluorescent organic probes for long-term imaging of lysosomes in live cells and tumor spheroids

P. Kumari, S. K. Verma and S. M. Mobin, Chem. Commun., 2018, 54, 539 DOI: 10.1039/C7CC07812A

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