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Issue 5, 2018
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Water soluble two-photon fluorescent organic probes for long-term imaging of lysosomes in live cells and tumor spheroids

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Abstract

The morphological alteration of lysosomes is a powerful indicator of various pathological disorders. In this regard, we have designed and synthesized a new water soluble fluorescent Schiff-base ligand (L-lyso) containing two hydroxyl groups. L-lyso exhibits excellent two-photon properties with tracking of lysosomes in live cells as well as in 3D tumor spheroids. Furthermore, it can label lysosomes for more than 3 days. Thus, L-lyso has an edge over the commercially available expensive LysoTracker probes and also over other reported probes in terms of its long-term imaging, water solubility and facile synthesis.

Graphical abstract: Water soluble two-photon fluorescent organic probes for long-term imaging of lysosomes in live cells and tumor spheroids

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Supplementary files

Article information


Submitted
09 Oct 2017
Accepted
13 Dec 2017
First published
13 Dec 2017

Chem. Commun., 2018,54, 539-542
Article type
Communication

Water soluble two-photon fluorescent organic probes for long-term imaging of lysosomes in live cells and tumor spheroids

P. Kumari, S. K. Verma and S. M. Mobin, Chem. Commun., 2018, 54, 539
DOI: 10.1039/C7CC07812A

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