A domain-based DNA circuit for smart single-nucleotide variant identification

Weiye Zhong; Weiyang Tang; Jin Fan; Junmin Zhang; Xuechang Zhou; Yizhen Liu

doi:10.1039/C7CC07733E

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A domain-based DNA circuit for smart single-nucleotide variant identification†

Weiye Zhong,^a Weiyang Tang,^a Jin Fan,^a Junmin Zhang,

^a Xuechang Zhou

^a and Yizhen Liu

*^a

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* Corresponding authors

^a College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, P. R. China
E-mail: yzliu@szu.edu.cn

Abstract

According to the differential information of four homologous oligonucleotides, two domain-based encoders have been constructed with the molecular information as the input. Based on the one-to-one correspondence between the input and output, SNVs can be identified and their sites can be located at the domain level.

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Article information

DOI: https://doi.org/10.1039/C7CC07733E
Article type: Communication
Submitted: 05 Oct 2017
Accepted: 17 Nov 2017
First published: 17 Nov 2017

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Chem. Commun., 2018,54, 1311-1314

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A domain-based DNA circuit for smart single-nucleotide variant identification

W. Zhong, W. Tang, J. Fan, J. Zhang, X. Zhou and Y. Liu, Chem. Commun., 2018, 54, 1311 DOI: 10.1039/C7CC07733E

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Chemical Communications

A domain-based DNA circuit for smart single-nucleotide variant identification†

Abstract

Supplementary files

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A domain-based DNA circuit for smart single-nucleotide variant identification

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