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Issue 15, 2018
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Enzymatically cleavable traceless biotin tags for protein PEGylation and purification

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Abstract

Here we report an example of a protein–PEG conjugate with a biotin tag cleavable by lipase-catalyzed hydrolysis. Very mild cleavage conditions, heterogeneous, easily separable catalysts, and traceless design make this method attractive for the preparation and purification of PEGylated proteins.

Graphical abstract: Enzymatically cleavable traceless biotin tags for protein PEGylation and purification

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Article information


Submitted
26 Jul 2017
Accepted
05 Jan 2018
First published
08 Jan 2018

Chem. Commun., 2018,54, 1913-1916
Article type
Communication

Enzymatically cleavable traceless biotin tags for protein PEGylation and purification

A. M. Wawro, Y. Aoki, T. Muraoka, K. Tsumoto and K. Kinbara, Chem. Commun., 2018, 54, 1913
DOI: 10.1039/C7CC05814D

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