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Gradiently degraded electrospun polyester scaffolds with cytotoxic for therapy of urothelial carcinoma

Abstract

Kidney-sparing surgery is the preferred treatment strategy for low risk upper tract urothelial carcinoma (UTUC). After this procedure, preventing the carcinoma recurrence in the ureter and supporting the ureter by a ureteral stent are required. The biodegradable drug-loaded ureteral scaffolds are able to maintain their long-term effective drug concentrations in the lesion sites without the defects of traditional ureteral stents, which may address the two issues simultaneously. The purpose of this study was to reveal the possibility for controlled delivery of epirubicin (EPI) by the gradiently degraded electrospun poly(ε-caprolactone) (PCL)/poly(lactide-co-glycolide) (PLGA) scaffolds to evaluate the antitumor activity against UTUC. The degradable PCL/PLGA scaffolds containing 15.0 or 25.0 wt.% of PCL and loading 0, 5.0, or 10.0 wt.% of EPI were successfully fabricated by electrospinning. In addition, the PCL/PLGA scaffolds showed sustained and controlled degradation and drug release kinetics, that is, the degradation and drug release rates were slow down with the increased ratio of PCL. The EPI-loaded PCL/PLGA scaffolds showed excellent antitumor activities both in vitro and in vivo without obvious systemic toxicity. All in all, the gradiently degraded EPI-loaded electrospun polyester scaffolds are potential ureteral stent tube for local inhibition of recurrence of UTUC, where the continued release of EPI can prevent the subsequent proliferation of residual tumor cells and the gradient degradation was consistent with the repair of ureter.

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Publication details

The article was received on 17 Oct 2018, accepted on 03 Dec 2018 and first published on 05 Dec 2018


Article type: Paper
DOI: 10.1039/C8BM01317A
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Gradiently degraded electrospun polyester scaffolds with cytotoxic for therapy of urothelial carcinoma

    J. wang, G. wang, H. Shan, X. Wang, C. Wang, X. Zhuang, J. Ding and X. Chen, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM01317A

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