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A pH-responsive hydrogel with potent antibacterial activity against both aerobic and anaerobic pathogens

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Abstract

Aminoglycosides are a family of antibiotics with a wide-spread antibacterial spectrum and high antibacterial activity. However, they are less effective against anaerobic pathogens due to the requirement of aerobic respiration to exert their antibacterial functions. Here, we prepared a pH-responsive hydrogel with potent antibacterial activities against both aerobic and anaerobic pathogens. The hydrogel was prepared by reacting oxidized dextran with aminoglycoside and an ornidazole analogue via an acid-labile Schiff base linkage. The prepared hydrogel was injectable, self-healing, biocompatible, and showed a pH-responsive drug release behavior. More importantly, the gel was efficient in killing both aerobic and anaerobic pathogens. This study provides a facile strategy to expand the antibacterial spectrum of aminoglycoside hydrogels.

Graphical abstract: A pH-responsive hydrogel with potent antibacterial activity against both aerobic and anaerobic pathogens

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Publication details

The article was received on 28 Sep 2018, accepted on 07 Nov 2018 and first published on 09 Nov 2018


Article type: Paper
DOI: 10.1039/C8BM01211C
Citation: Biomater. Sci., 2018, Advance Article
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    A pH-responsive hydrogel with potent antibacterial activity against both aerobic and anaerobic pathogens

    J. Hu, Z. Zheng, C. Liu, Q. Hu, X. Cai, J. Xiao and Y. Cheng, Biomater. Sci., 2018, Advance Article , DOI: 10.1039/C8BM01211C

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