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A polyhedral oligomeric silsesquioxane/molecular sieve codoped molecularly imprinted polymer for gastroretentive drug-controlled release in vivo

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Abstract

Flotation drug delivery system (FDDS) is recognized as an efficient means to improve the therapeutic efficiency and enhance the drug bioavailability. Herein, we have developed a molecularly imprinted polymer (MIP) against capecitabine (CAP) to fabricate a FDDS by exploiting polyhedral oligomeric silsesquioxane (POSS) and Mobil composition of matter no. 41 (MCM-41) as the codopant. The synergistic effect of POSS and MCM-41 endows MIPs with enhanced imprinting effect and improved mass transfer efficiency. The impacts of the type of dopant, the type of functional monomer, the template/functional monomer ratio and the functional monomer/cross-linker ratio on imprinting effect have been investigated in detail. The POSS/MCM-41 codoped MIPs present favourable sustained release property in vitro and in vivo, displaying a high relative bioavailability of 173.4%. The proposed MIPs with high selectivity and superior physical and chemical stability exhibit potential as an alternative drug carrier applied in FDDS.

Graphical abstract: A polyhedral oligomeric silsesquioxane/molecular sieve codoped molecularly imprinted polymer for gastroretentive drug-controlled release in vivo

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Publication details

The article was received on 12 Sep 2018, accepted on 24 Sep 2018 and first published on 28 Sep 2018


Article type: Paper
DOI: 10.1039/C8BM01124A
Citation: Biomater. Sci., 2018, Advance Article
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    A polyhedral oligomeric silsesquioxane/molecular sieve codoped molecularly imprinted polymer for gastroretentive drug-controlled release in vivo

    X. Wang, F. Yang, L. Zhang, Y. Huang and Z. Liu, Biomater. Sci., 2018, Advance Article , DOI: 10.1039/C8BM01124A

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